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T*
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[(27,36)-7.8(38)]TJ
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(35,36)Tj
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[(but)-268.4(inamma)10.6(tory-)]TJ
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T*
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T*
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T*
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T*
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[(the)-505.7(proinammatory)-504.1(cytokine)-501(interleukin)-504.5(\(IL\)-12)-498.4(and)-499.8(in-)]TJ
T*
[(creases)-443.9(of)-439.9(the)-442.3(anti-inammatory)-438.6(cytokine)-443.4(IL-10.)]TJ
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[(document)-623(reductions)-623.9(in)-612.9(circulating)-626.6(levels)-619.5(of)-618.5(C-reactive)]TJ
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[(protein)-297.1(\(CRP\))-295.3(and)-292.4(IL-6,)]TJ
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(49,50,53)Tj
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[(although)-292.5(these)-295.7(ndings)-295.5(were)]TJ
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[(not)-781(replicated)-787.8(by)-779.8(some)-778.4(investigators.)]TJ
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(48)Tj
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[(Some)-784.2(of)-779.7(the)]TJ
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T*
[(in)-370.9(sympathetic)-374.1(nervous)-371.5(system)-371.6(activation,)-369.8(as)-371.8(evidenced)-371.8(by)]TJ
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[(parallel)-600.1(reductions)-595.1(in)-589.8(levels)-596.5(of)-589.7(the)-597.8(catecholamines)-599.8(epi-)]TJ
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[(nephrine)-569.9(and)-563.2(norepinephrine.)]TJ
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(47,52,54)Tj
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[(Studies)-567.5(also)-564.2(suggest)]TJ
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[(differential)-391.5(effects)-385.4(of)-388.1(meditation)-383.7(practices)-389(on)-388.1(immune)-384.7(cell)]TJ
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[(and)-338.5(adaptive)-335.1(immune)-332.9(systems.)]TJ
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(55,56)Tj
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8.9663 0 0 8.9663 62.022 749.6502 Tm
(2)Tj
46.3849 0 TD
[(BUSHELL)-338(ET)-338.7(AL.)]TJ
ET
endstream
endobj
45 0 obj
<>stream
/GS1 gs
BT
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[(The)-299.4(benets)-303.6(of)-295.9(yoga)-305.1(therapies)-301.4(on)-295.9(the)-304.1(health)-297.2(of)-301.7(the)-298.3(innate)]TJ
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[(immune)-505.7(system)-504.1(have)-502.1(also)-500.8(been)-507.8(demonstrated)-501.8(in)-503.4(a)-503.4(study)]TJ
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T*
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T*
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[(-defensin)-242.5(and)-234.9(HBD-2)-244.4(expression.)]TJ
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(57)Tj
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(58)Tj
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[(Yoga)-478.7(ther-)]TJ
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[(ceptors)-413.1(tumor)-404.3(necrosis)-408.3(factor)-412.2(\(TNF\)-RII)-410.1(and)-407.6(IL-1RA,)-404.7(and)]TJ
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(59)Tj
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[(Epel)-577.1(et)-579.5(al.)-577.1(showed)-578.7(that)-581.8(combined)]TJ
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[(mantra-based)-283.9(meditation)-274.3(and)-275.2(yoga)-276.3(asana)-279.5(practices)-279.5(regulated)]TJ
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[(levels)-389.1(of)-382.3(the)-379(proin)-6.5(ammatory)-382.3(cytokine)-385.8(TNF-)]TJ
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18.7363 0 TD
(a)Tj
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[(and)-384.6(metab-)]TJ
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[(olism)-703.7(of)-704.8(the)-701.5(Alzheimers)-708.9(disease-associated)-713(amyloid-)]TJ
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23.7415 0 TD
(b)Tj
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(protein,)Tj
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(60)Tj
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[(and)-471(also)-472(reported)-477.7(reduced)-471.9(expression)-473.8(of)-474.5(proin-)]TJ
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[(ammatory)-314.1(genes)-312.9(in)-313.4(association)-315.1(with)-310.8(a)-313.3(meditation)-314.6(practice.)]TJ
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T*
[(article,)-297.2(paired)-297(with)-287.8(ndings)-295.5(to)-290.3(date)-294.8(from)-293.5(COVID-19)-294.6(studies)]TJ
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[(reporting)-535.4(cytokine)-529.8(values.)-530.7(Figure)-531.8(1)-531(presents)-535(effect)-534.3(sizes)]TJ
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[(from)-362.7(Table)-360.5(1.)-361.6(It)-359.4(is)-359.2(evident)-367.4(that)-357.2(effect)-367.3(sizes)-358.9(are)-362.7(larger)-366.1(with)]TJ
T*
[(COVID-19.)-384.5(The)-385.8(signicance)-385.3(of)-376.5(the)-379(presentation,)-388.9(however,)]TJ
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[(is)-451.4(to)-451.6(show)-454.3(the)-453.8(relevant)-456(overlap)-453.6(and)-453.7(general)-454.8(directions)-451.2(of)]TJ
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[(effects)-471.8(on)-463(cytokines)-467.3(and)-465.2(that)-466.6(these)-468.5(practices)-469.6(can)-466.4(provide)]TJ
T*
[(systemic)-277.2(regulatory)-272.7(effects)-270.3(on)-272.9(a)-267.2(range)-272.7(of)-272.9(cytokines.)-274.9(It)-267.2(is)-272.8(im-)]TJ
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[(portant)-245.2(to)-238.5(note)-241.8(that)-242(the)-240.7(reviewed)-243.7(studies)-239.1(were)-243.7(on)-238.3(more)-242.9(short-)]TJ
0 -1.1116 TD
[(term)-496.5(practitioners)-496.1(of)-491.7(the)-488.4(modalities)-498.7(where)-492.5(such)-489.2(cytokine)]TJ
T*
[(data)-277.6(are)-276.3(available.)-277.6(There)-273.9(is)-272.8(a)-273(fairly)-278.7(large)-272.9(literature,)-277.6(although)]TJ
T*
[(comparing)-388(the)-379(effects)-385.4(of)-382.3(longer)-382.2(term)-387(compared)-382.1(with)-385.7(more)]TJ
0 -1.1174 TD
[(novice)-400.7(practitioners,)-395.9(that)-397.5(shows)-391.9(signicantly)-401.6(larger)-394.9(effects)]TJ
0 -1.1116 TD
[(with)-276.2(longer)-272.8(practice)-278.6(in)-273(domains,)-278.4(for)-273.9(example,)-275.2(of)-272.9(autonomic,)]TJ
T*
[(neurohormonal,)-234.5(and)-223.3(brain)-231.4(functioning.)]TJ
7.3823 0 0 6.5614 211.748 400.7621 Tm
(6163)Tj
9.843 0 0 9.843 232.4976 396.3968 Tm
[(Needed)-229.8(are)-230.2(stud-)]TJ
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[(ies)-309.7(of)-301.7(immune)-304.1(function)-303.9(in)-307.6(longer)-301.6(term)-306.4(practitioners)-306.1(directly)]TJ
0 -1.1116 TD
[(compared)-370.6(with)-368.4(novice)-366.2(practitioners,)-372.8(although)-367.3(some)-369.5(studies)]TJ
T*
[(have)-657.6(examined)-664.5(immune-related)-662.2(proles)-653.7(in)-658.9(longer)-658.7(term)]TJ
0 -1.1174 TD
[(meditators)-337.3(compared)-341.8(with)-333.8(nonpractitioner)-337.3(controls.)]TJ
7.3823 0 0 6.5614 265.7763 356.9385 Tm
(6466)Tj
9.843 0 0 9.843 69.7323 341.5747 Tm
[(Furthermore,)-416.4(according)-416.7(to)-411.3(a)-417(small)-411.1(but)-412.4(relevant)-415.7(body)-413.3(of)]TJ
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[(research,)-477.4(certain)-472.2(meditation)-475.9(and)-471(yoga)-472.1(practices)-475.4(bring)-466.4(an-)]TJ
T*
[(other)-363.9(set)-361.5(of)-365(key)-361.6(neuroendocrine)-365.7(factors)-361.2(into)-361.8(the)-361.7(picture,)-365(in)]TJ
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[(particular)-636.9(melatonin,)-633.6(which)-629.7(in)-630.1(addition)-632.4(to)-630.1(its)-625.4(systemic)]TJ
25.5097 42.3108 TD
[(health-promoting)-315.4(properties)-312.8(has)-309.5(benecial)-319.9(effects)-310.6(on)-313.2(mood,)]TJ
0 -1.1174 TD
[(affect,)-382.2(emotion,)-382.4(and)-384.6(mental)-379(state)-388(and)-378.8(functioning.)]TJ
7.3823 0 0 6.5614 514.8282 718.5825 Tm
(26,27,67,68)Tj
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[(Studies)-331.3(provide)-337.3(insight)-330.4(into)-333(the)-332.9(epigenetic)-332.8(and)-332.8(microbiome)]TJ
0 -1.1116 TD
[(pathways)-490(of)-491.7(complementary)-494(practices)-492.7(relevant)-496.3(to)-486.1(inam-)]TJ
T*
[(matory)-331.6(processes.)]TJ
7.3823 0 0 6.5614 382.2802 685.7006 Tm
[(24,)-9.4(6466,69)]TJ
/F6 1 Tf
8.9663 0 0 8.9663 310.8472 653.8959 Tm
[(Meditation)-339.7(and)-329(Yoga)-334(May)-338(Potentially)-339.5(Enhance)]TJ
0 -1.2203 TD
[(the)-330.4(Activity)-340.1(of)-336.9(Melatonin,)-333.5(One)-336.8(of)-336.9(the)-330.4(Most)-338.5(Benecial)]TJ
T*
[(Pleiotropic)-337.8(Natural)-332.6(Substances)-340.1(Known)]TJ
/F4 1 Tf
9.843 0 0 9.843 320.8251 615.5715 Tm
[(The)-420.4(functions)-420.1(of)-422.6(melatonin)-422.8(are)-420.3(extensive.)-425.8(In)-422.6(the)-419.3(words)]TJ
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[(of)-699.1(leading)-695.7(melatonin)-705(researcher)-701.9(Russell)-700.9(Reiter)-701.4(of)-699.1(the)]TJ
0 -1.1116 TD
[(University)-491.3(of)-486(Texas,)-490.3(writing)-487(in)-486.1(the)-488.4(life)-489.6(sciences)-491.3(journal,)]TJ
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T*
(Physiology)Tj
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4.458 0 TD
[(,)-389.3(and)-384.6(referring)-392.4(to)-388.2(thousands)-391(of)-388.1(published)-391.3(scien-)]TJ
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(70)Tj
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T*
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T*
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T*
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(68)Tj
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T*
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T*
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T*
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[(73,7)-8.6(4)]TJ
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(Fur-)Tj
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[(75,)-9.4(76)]TJ
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ET
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f
59.754 68.372 490.167 .28348 re
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59.754 246.557 490.167 .22676 re
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BT
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[(0.330)-4994.2(Carlson)-331.6(et)-337.3(al.)]TJ
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[(0.493)-4297.4(0.493)-2541.1(IL-10)-5603.4(0.118)]TJ
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[(Chen)-334.4(et)-337.3(al.)]TJ
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[(Qin)-338(et)-331.6(al.)]TJ
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[(2.911)-4297.4(2.722)-2541.1(IL-6)]TJ
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[(Wang)-335.5(et)-337.3(al.)]TJ
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[(2.533)-22310.2(0.582)-4994.2(Cahn)-334.4(et)-331.6(al.)]TJ
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[(3.008)-4297.4(3.008)-2541.1(TNF-)]TJ
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