Six-Day Clinical Trial Finds Integrative Medicine Program Alters Blood Serum
Meditation, yoga and vegetarian diet linked to decline in plasma metabolites associated with inflammation and cardiovascular disease risk
In a novel controlled clinical trial, participants in a six-day Ayurvedic-based well-being program that featured a vegetarian diet, meditation, yoga and massages experienced measurable decreases in a set of blood-based metabolites associated with inflammation, cardiovascular disease risk and cholesterol regulation.
View the Study: Integrative Medicine Program Alters Blood Serum
The findings, published in the September 9 issue of Scientific Reports, represent a rare attempt to use metabolic biomarkers to assess the reported health benefits of integrative medicine and holistic practices. Senior author of the study, which included researchers from multiple institutions, was Deepak Chopra, MD, clinical professor in the Department of Family Medicine and Public Health at University of California San Diego School of Medicine and a noted proponent of integrative medicine.
“It appears that a one-week Panchakarma-based program can significantly alter the metabolic profile of the person undergoing it,” said Chopra, whose foundation provided and managed funding for the study. “As part of our strategy to create a framework for whole systems biology research, our next step will be to correlate these changes with both gene expression and psychological health.”
Study co-author Paul J. Mills, PhD, professor of family medicine and public health and director of the Center of Excellence for Research and Training in Integrative Health, both at UC San Diego, noted that alternative and integrative medicine practices, such as meditation and Ayurveda, are extremely popular, but their effects on the human microbiome, genome and physiology are not fully understood. “Our program of research is dedicated to addressing these gaps in the literature.”
We looked at the effects of a Panchakarma-based Ayurvedic intervention on plasma metabolites in a controlled clinical trial,” said lead author Christine Tara Peterson, PhD, a postdoctoral fellow at UC San Diego. Panchakarma refers to a detoxification and rejuvenation protocol involving massage, herbal therapy and other procedures to help strengthen and rejuvenate the body.”
The study involved 119 healthy male and female participants between 30 and 80 years of age who stayed at the Chopra Center for Wellbeing in Carlsbad, Calif. Slightly more than half were assigned to the Panchakarma intervention (the Chopra Center’s Perfect Health program, which prices start at $2865 for a six-day treatment). The remainder to a relaxation control group. Blood plasma analyses, using liquid chromatography and mass spectrometry, were taken before and after the six-day testing period.
The researchers found that in the Panchakarma group there was a measurable decrease in 12 specific cell-membrane chemicals (phosphatidylcholines) correlating with serum cholesterol and inversely related to Type 2 diabetes risk.
“These phospholipids exert broad effects on pathways related to inflammation and cholesterol metabolism,” said Peterson. “Plasma and serum levels of the metabolites of phosphatidylcholine are highly predictive of cardiovascular disease risk.”
Application of a less stringent measurement standard identified 57 additional metabolites differentially abundant between the two groups of participants, which included additional phosphatidylcholines, sphingomyelins, and others. The authors suggested that given the very short duration of the trial, the serum profile changes were likely driven by the vegetarian diet component of Panchakarma. They said further studies were needed to more fully understand the processes and mechanisms involved.
Co-authors include Arthur M. Moseley, Joseph Lucas, Lisa St John Williams and P. Murali Doraiswamy, Duke University; Elizabeth H. Blackburn and Elissa E. Epel, UC San Francisco; Sheila Patel and Valencia Porter, UC San Diego and The Chopra Center for Wellbeing; Scott N. Peterson, Sanford Burnham Prebys Medical Discovery Institute; Eric E. Schadt, Steven R. Steinhubl and Eric J. Topol, Scripps Translational Science Institute; and Rudolph E. Tanzi, Harvard University.
Funding for this research came, in part, from the Fred Foundation, the MCJ Amelior Foundation, the National Philanthropic Trust, the Walton Family Foundation, the Chopra Foundation and Sybil Robson Orr.
Disclosures: Deepak Chopra is founder of the Chopra Foundation and co-founder of the Chopra Center for Wellbeing. Paul Mills is director of research at the Chopra Foundation.
Full study: Peterson, C. T. et al. Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects. Sci. Rep. 6, 32609; doi: 10.1038/srep32609 (2016).